About

Welcome to TWISTED VAPE AND SMOKE

Twisted Vape & Smoke is the ultimate destination for any kind of vape product like E- Juice, vape mods, and accessories.

We offer our customers a new age alternative to tobacco smoking with the latest products and best accessories is available in the market.

We aim to completely change the smoking scene for smokers and non-smokers alike.

We can always guarantee consistency in both flavor and quality and always provide the best products.

We also want to help you quit smoking and hence our collection always includes the top-range nicotine salts mixed with unique and widely chosen flavors.

Always get what your heart desires at Twisted Vape and Smoke, we are always happy to bring you the best.

Why do we Vape?

Abstract

1. Nicotine improves attention in a wide variety of tasks in healthy volunteers. 2. Nicotine improves immediate and longer-term memory in healthy volunteers. 3. Nicotine improves attention in patients with probable Alzheimer’s Disease. 4. While some of the memory effects of nicotine may be due to enhanced attention, others seem to be the result of improved consolidation as shown by post-trial dosing.

Nicotine is a nootropic that is dosed at 1 – 2 mg on an as-needed basis.

 

Why we Smoke Cannabis 

The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.